Ethylamine → HCID 69208709, compound

HRID 2252057Notes

Reaction equation

HRID 2252057 reaction equation
[C:1]([Si:5]([CH3:33])([CH3:32])[O:6][CH:7]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:8]([C:10]1[CH:25]=[CH:24][C:13]2[N:14]=[C:15](Cl)[N:16]([S:17]([CH:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])[C:12]=2[CH:11]=1)=[O:9])([CH3:4])([CH3:3])[CH3:2].[CH2:34]([NH2:36])[CH3:35]>C1COCC1>[C:1]([Si:5]([CH3:33])([CH3:32])[O:6][CH:7]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:8]([C:10]1[CH:25]=[CH:24][C:13]2[N:14]=[C:15]([NH:36][CH2:34][CH3:35])[N:16]([S:17]([CH:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])[C:12]=2[CH:11]=1)=[O:9])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 69208744HCID 69208744, compound

Product 1

HCID 69208709HCID 69208709, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepare essentially as described in the previous preparation (Preparation 97) starting from 2-(tert-butyldimethyl-silyloxy)-1-[2-chloro-3-(propane-2-sulfonyl)-3H-benzimidazol-5-yl]-2-phenyl-ethanone (760 mg, 1.50 mmol), ethyl amine (0.25 mL, 4.50 mmol, 3 equiv) in 2 mL of THF. Yield: 84%. MS(ES+): m(z=516.3 (M+H)+

Workup

  1. customPrepare essentially
  2. customas described in the previous preparation (Preparation 97)

Sources & evidence

ORD record
ord-0623393c57df471a8685909d9dbf951b
Source dataset
uspto-grants-2008_01
Patent number
US07320995B2

Reaction notes

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