Hydrochloric Acid → HCID 17981752, compound

HRID 2252079Notes

Reaction equation

HRID 2252079 reaction equation
[CH:1]([S:4]([N:7]1[C:11]2[CH:12]=[C:13]([C:16]3[N:20]([CH:21]4[CH2:26][CH2:25][CH:24]([NH:27]C(OC(C)(C)C)=O)[CH2:23][CH2:22]4)[CH:19]=[N:18][C:17]=3[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:41])(=[O:6])=[O:5])([CH3:3])[CH3:2].[ClH:42]>C(O)(=O)C>[ClH:42].[CH:1]([S:4]([N:7]1[C:11]2[CH:12]=[C:13]([C:16]3[N:20]([CH:21]4[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]4)[CH:19]=[N:18][C:17]=3[C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:41])(=[O:5])=[O:6])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69207373HCID 69207373, compound

Product 1

HCID 17981752HCID 17981752, compoundYield 15%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Stir a solution of 1-isopropylsulfonyl-2-amino-6-(1-(4-(N-[tert-butoxycarbonyl]amino)cyclohex-1-yl)-4-(phenyl)-imidazol-5-yl)-benzimidazole (0.14 g, 0.2 mmol) in 1 M hydrogen chloride in acetic acid (5 mL) at room temperature for 1 hour. Filter the suspension and dry the solid to provide 0.017 g (15%) of the title compound. MS(ES+): m/z=479.0 (M+H)+

Workup

  1. filtrationFilter the suspension
  2. customdry the solid

Sources & evidence

ORD record
ord-d66e9d0fe7f1446ca1fdff92d3084a45
Source dataset
uspto-grants-2008_01
Patent number
US07320995B2

Reaction notes

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