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温度

0 °C

To a mixture of Example 332C (3.8 g, 23.6 mmol) and triethylamine (4.3 mL, 30.7 mmol) in tetrahydrofuran (50 mL) was added methanesulfonyl chloride (2.2 mL, 28.3 mmol) dropwise at about 0° C. After about 30 min stirring at about 0° C., the reaction mixture was diluted with water and was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4), filtered and evaporated under reduced pressure to give the above intermediate. MS (DCI/NH3): m/z 258 (M+NH4)+.

1. extractionwas extracted with ethyl acetate
2. washThe combined organic extracts were washed with brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated under reduced pressure
6. customto give the above intermediate