Water → HCID 69248711, compound

HRID 2252288Notes

Reaction equation

HRID 2252288 reaction equation
O.[F:2][C:3]([F:8])([F:7])[C:4]([OH:6])=[O:5].[CH3:9][C:10]([CH3:55])([CH3:54])[C:11]([O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][C:27]3[C:32](=[O:33])[N:31]([C:34]4[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=4)[N:30]=[CH:29][C:28]=3[N:41]3[CH2:46][CH2:45][N:44](C(OC(C)(C)C)=O)[CH2:43][CH2:42]3)=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)=[O:12]>ClCCl>[F:2][C:3]([F:8])([F:7])[C:4]([OH:6])=[O:5].[C:11]([O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]([O:26][C:27]3[C:32](=[O:33])[N:31]([C:34]4[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=4)[N:30]=[CH:29][C:28]=3[N:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[CH:24][CH:25]=2)=[CH:16][CH:15]=1)(=[O:12])[C:10]([CH3:55])([CH3:54])[CH3:9]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 58585365HCID 58585365, compound

Product 1

HCID 69248711HCID 69248711, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.2 ml of water and 2.2 ml of trifluoroacetic acid are added dropwise to a solution of 568 mg (0.889 mmol) of the compound from Example 2 in 4.5 ml of dichloromethane at room temperature. After 45 min, the reaction mixture is concentrated and thoroughly dried under high vacuum.

Workup

  1. concentrationthe reaction mixture is concentrated
  2. customthoroughly dried under high vacuum

Sources & evidence

ORD record
ord-714a3ff9a210468eb6eafaee2abc97fb
Source dataset
uspto-grants-2008_01
Patent number
US07320977B2

Reaction notes

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