HRID2252288

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID6422

未命名化合物

结构：Cc1ccc(-n2ncc(N3CCN(C(=O)OC(C)(C)C)CC3)c(Oc3ccc(-c4ccc(OC(=O)C(C)(C)C)cc4)cc3)c2=O)cc1

HCID58585365

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(-n2ncc(N3CCNCC3)c(Oc3ccc(-c4ccc(OC(=O)C(C)(C)C)cc4)cc3)c2=O)cc1.O=C(O)C(F)(F)F

HCID69248711

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

0.2 ml of water and 2.2 ml of trifluoroacetic acid are added dropwise to a solution of 568 mg (0.889 mmol) of the compound from Example 2 in 4.5 ml of dichloromethane at room temperature. After 45 min, the reaction mixture is concentrated and thoroughly dried under high vacuum.

WORKUP

后处理

concentrationthe reaction mixture is concentrated
customthoroughly dried under high vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-714a3ff9a210468eb6eafaee2abc97fb
来源数据集: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07320977B2
来源说明: uspto-grants-2008_01

反应 SMILES

O.[F:2][C:3]([F:8])([F:7])[C:4]([OH:6])=[O:5].[CH3:9][C:10]([CH3:55])([CH3:54])[C:11]([O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][C:27]3[C:32](=[O:33])[N:31]([C:34]4[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=4)[N:30]=[CH:29][C:28]=3[N:41]3[CH2:46][CH2:45][N:44](C(OC(C)(C)C)=O)[CH2:43][CH2:42]3)=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)=[O:12]>ClCCl>[F:2][C:3]([F:8])([F:7])[C:4]([OH:6])=[O:5].[C:11]([O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]([O:26][C:27]3[C:32](=[O:33])[N:31]([C:34]4[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=4)[N:30]=[CH:29][C:28]=3[N:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)=[CH:24][CH:25]=2)=[CH:16][CH:15]=1)(=[O:12])[C:10]([CH3:55])([CH3:54])[CH3:9]