反应详情

To a pre-cooled solution (0° C.) of the compound from Step F of Example 2 (140 mg, 0.50 mmol) in DMF (2.5 mL) was added N-chlorosuccinimide (0.075 g, 0.55 mmol) in DMF (0.5 mL) dropwise. The solution was stirred at room temperature for 1 h and the reaction quenched by addition of methanol (4 mL) and evaporated in vacuo. The crude product was purified on silica gel using methanol/dichloromethane (1:9) as eluent. Fractions containing the product were pooled and evaporated in vacuo to give the desired product (55 mg) as a colorless solid.

1. customthe reaction quenched by addition of methanol (4 mL)
2. customevaporated in vacuo
3. customThe crude product was purified on silica gel
4. additionFractions containing the product
5. customevaporated in vacuo