Hydrochloric Acid → 4-Bromo-2-{[(2R)-morpholin-2-yl]methyl}phenol

HRID 2252969Notes

Reaction equation

HRID 2252969 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][C:15]2[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=2[OH:22])[CH2:9]1)(OC(C)(C)C)=O.Cl>>[Br:21][C:19]1[CH:18]=[CH:17][C:16]([OH:22])=[C:15]([CH:20]=1)[CH2:14][C@H:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58689695N-Boc-(R)-2-(5-bromo-2-hydroxybenzyl)morpholine

Product 1

HCID 586897094-Bromo-2-{[(2R)-morpholin-2-yl]methyl}phenol

Procedure

Deprotection of N-Boc-(R)-2-(5-bromo-2-hydroxybenzyl)morpholine, using hydrogen chloride (4M, in methanol), afforded the morpholine example 1 as an off-white solid (51 mg, 100%).

Sources & evidence

ORD record
ord-afc4bd7fa5534e3686f9306bdd5ffc8d
Source dataset
uspto-grants-2008_01
Patent number
US07323466B2

Reaction notes

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