2-Methoxyethylamine → HCID 12784103, compound

HRID 225344Notes

Reaction equation

HRID 225344 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH2:24][O:25][CH3:26])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])[CH3:2].[CH3:28][O:29][CH2:30][CH2:31][NH2:32].C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH2:24][O:25][CH3:26])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1[NH:32][CH2:31][CH2:30][O:29][CH3:28])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 80182-MethoxyethylamineHCID 10340Sodium CarbonateHCID 12784120HCID 12784120, compound

Product 1

HCID 12784103HCID 12784103, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 2.4 g. (0.006 mole) of 5-chloro-7,8-dihydro-8-(2-methoxyethyl)-7-oxo-2-phenyl-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester in 100 ml. of ethanol was added 0.45 g. (0.006 mole) of 2-methoxyethylamine and 0.65 g. (0.006 mole) of Na2CO3. This mixture was refluxed 3 hours, then filtered and the filtrate chilled. A solid formed amd was filtered off and rinsed with petroleum ether--m.p. 160°-163° C. No further purification was necessary.

Workup

  1. temperatureThis mixture was refluxed 3 hours
  2. filtrationfiltered
  3. temperaturethe filtrate chilled
  4. customA solid formed amd
  5. filtrationwas filtered off
  6. washrinsed with petroleum ether
  7. customNo further purification

Sources & evidence

ORD record
ord-154c51559b814fff93443e69f94b7e51
Source dataset
uspto-grants-1980_11
Patent number
US04236004

Reaction notes

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