Hydrochloric Acid → HCID 19746158, compound

HRID 2253656Notes

Reaction equation

HRID 2253656 reaction equation
[O:1]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:14]>CC(O)C.CCOCC>[ClH:14].[O:1]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 2005103-Phenoxypyridine

Product 1

HCID 19746158HCID 19746158, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent2×

Procedure

A solution of 10 g. of 3-phenoxypyridine in 10 ml. of 2-propanol is treated with an excess of a solution of dry hydrogen chloride in 2-propanol. The resulting solution is stirred and diluted with ether to give a yellow oil. The oil is separated, triturated several times with ether to give 3-phenoxypyridine hydrochloride as a crystalline solid; m.p. 112°-113.5° C. after recrystallization from 2-propanolether followed by drying at reduced pressure.

Workup

  1. customto give a yellow oil
  2. customThe oil is separated
  3. customtriturated several times with ether

Sources & evidence

ORD record
ord-39abb327cfe74217aa40e497b161affd
Source dataset
uspto-grants-1993_08
Patent number
US05232934

Reaction notes

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