1,3-Propanedithiol → HCID 15020331, compound

HRID 2253671Notes

Reaction equation

HRID 2253671 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:13])([CH3:12])[C@@H:7]([OH:14])[C@@H:6]2[N:15]=[N+]=[N-])#[N:2].C(N(CC)CC)C.C(S)CCS>CO>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:13])([CH3:12])[C@@H:7]([OH:14])[C@@H:6]2[NH2:15])#[N:2]

Participants

5

Reactant 3

HCID 80131,3-PropanedithiolHCID 8471TriethylamineHCID 86745117HCID 86745117, compound

Product 1

HCID 15020331HCID 15020331, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of trans-5-cyano-1,1-dimethyl-3-azido-indan-2-ol (0.93 g), triethylamine (1.2 ml) and 1,3-propanedithiol (0.9 ml) in dry methanol (20 ml) was stirred at room temperature for 48 h. After filtration, the solution was evaporated in vacuo to give the title compound (0.79 g) as a gum.

Workup

  1. filtrationAfter filtration
  2. customthe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-e7438cf54bfb409faae6fdff2c89c3a4
Source dataset
uspto-grants-1993_08
Patent number
US05232938

Reaction notes

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