Potassium Carbonate → HCID 54277012, compound

HRID 2254054Notes

Reaction equation

HRID 2254054 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:5]2=[O:19].C(=O)([O-])[O-].[K+].[K+].[Br:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[C:29]([F:35])[CH:28]=1>CN(C)C=O>[Br:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][N:8]2[C:9]3[C:4](=[CH:3][C:2]([Cl:1])=[CH:11][CH:10]=3)[C:5](=[O:19])[N:6]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:7]2=[O:12])=[C:29]([F:35])[CH:28]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27336604-Bromo-2-fluorobenzyl bromideHCID 54218485HCID 54218485, compound

Product 1

HCID 54277012HCID 54277012, compoundYield 72.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Into 250 ml of dried dimethylformamide were dissolved 10 g of ethyl 6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetate, and 4.86 g of potassium carbonate were added and 10.40 g of 4-bromo-2-fluorobenzyl bromide were added under stirring. After stirring for 1 hour at 60° C., the reaction mixture was poured into 400 ml of ice water and the crystals were collected by filtration. They were recrystallized from ethanol to obtain 12.0 g of title compound. m.p. 145°-146° C.

Workup

  1. additionwere added
  2. stirringAfter stirring for 1 hour at 60° C.
  3. filtrationthe crystals were collected by filtration
  4. customThey were recrystallized from ethanol

Sources & evidence

ORD record
ord-c3fbd950393544c984c68a961f96b069
Source dataset
uspto-grants-1993_08
Patent number
US05234928

Reaction notes

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