Dimethylformamide → HCID 19744040, compound

HRID 2254063Notes

Reaction equation

HRID 2254063 reaction equation
CN(C)C=O.[O:6]=[C:7]1[N:16]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:15](=[O:23])[C:14]2[C:9](=[CH:10][C:11]([C:25]3[NH:26][CH:27]=[CH:28][N:29]=3)=[C:12]([F:24])[CH:13]=2)[NH:8]1.C(=O)([O-])[O-].[K+].[K+].[Cl:36][C:37]1[CH:44]=[C:43]([Cl:45])[CH:42]=[CH:41][C:38]=1[CH2:39]Cl>O>[Cl:36][C:37]1[CH:44]=[C:43]([Cl:45])[CH:42]=[CH:41][C:38]=1[CH2:39][N:8]1[C:9]2[C:14](=[CH:13][C:12]([F:24])=[C:11]([C:25]3[NH:29][CH:28]=[CH:27][N:26]=3)[CH:10]=2)[C:15](=[O:23])[N:16]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:7]1=[O:6]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 72122,4-Dichlorobenzyl chlorideHCID 11430Potassium CarbonateHCID 19744055HCID 19744055, compound

Product 1

HCID 19744040HCID 19744040, compoundYield 65.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

Into 50 ml of dimethylformamide were dissolved 2.33 g of ethyl 1,4-dihydro-2,4-dioxo-6-fluoro-7-imidazolyl-3(2H)-quinazolineacetate, and, after added 0.97 g of potassium carbonate and 1.51 g of 2,4-dichlorobenzyl chloride, the mixture was stirred for 5 hours at 100° C. After cooling by allowing to stand, the reaction mixture was poured into 500 ml of water and the deposits were collected by filtration. They were recrystallized from ethanol to obtain 2.25 g of title compound. m.p. 192°-193° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe deposits were collected by filtration
  3. customThey were recrystallized from ethanol

Sources & evidence

ORD record
ord-84f51831a4aa4aaa9ca99a3b473b6259
Source dataset
uspto-grants-1993_08
Patent number
US05234928

Reaction notes

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