Hydroxyamine hydrochloride → HCID 19007852, compound

HRID 2254097Notes

Reaction equation

HRID 2254097 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH:10]1[CH2:16][CH:15]2[N:17]([CH3:18])[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)=O.[ClH:19].[NH2:20][OH:21].C([O-])(=O)C.[NH4+]>C(O)C.O>[ClH:19].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[C:8](/[CH:10]1[CH2:16][CH:15]2[N:17]([CH3:18])[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)=[N:20]\[OH:21]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517165Ammonium AcetateHCID 9837778HCID 9837778, compound

Product 1

HCID 19007852HCID 19007852, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A mixture of (2-fluorophenyl)(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)methanone (29.5 g), hydroxylamine hydrochloride (16.5 g) and ammonium acetate (27.5 g) were heated in 80 ml of refluxing ethanol-water (3:1 mixture) for 19 hours. The mixture was cooled and the precipitated product was collected (25.2 g).

Workup

  1. temperatureThe mixture was cooled
  2. customthe precipitated product was collected (25.2 g)

Sources & evidence

ORD record
ord-f9dd961454204341ad0eb2e44ee9113f
Source dataset
uspto-grants-1993_08
Patent number
US05234931

Reaction notes

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