Hydroxyamine hydrochloride → HCID 19010520, compound

HRID 2254100Notes

Reaction equation

HRID 2254100 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:17][CH:16]2[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=O.[ClH:20].[NH2:21][OH:22].C([O-])(=O)C.[NH4+]>C(O)C.O>[ClH:20].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[C:9](/[CH:11]1[CH2:17][CH:16]2[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[N:21]\[OH:22]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517165Ammonium AcetateHCID 19007838HCID 19007838, compound

Product 1

HCID 19010520HCID 19010520, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A mixture of (2,4-difluorophenyl)(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)methanone (20 g), hydroxylamine hydrochloride (10.6 g) and ammonium acetate (18.7 g) was heated in 67.5 ml of refluxing ethanol-water (3.2 mixture) for 19 hours. The mixture was concentrated to approximately half of its original volume, and the precipitated solid (21.3 g) was collected.

Workup

  1. concentrationThe mixture was concentrated to approximately half of its original volume
  2. customthe precipitated solid (21.3 g) was collected

Sources & evidence

ORD record
ord-427ddfdb2e334753a782bc643eda21c5
Source dataset
uspto-grants-1993_08
Patent number
US05234931

Reaction notes

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