Hydrochloric Acid → HCID 9950812, compound

HRID 2254129Notes

Reaction equation

HRID 2254129 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:25])=[C:5]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:6]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].[H-].[Na+].[CH3:28]I.Cl>COCCOC>[CH3:28][N:3]1[C:4]([CH3:25])=[C:5]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:6]([C:13]2[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=2)[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:2]1[CH3:1]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 680274Diethyl 1,4-dihydro-2,6-dimethyl-4-(4-fluorophenyl)-3,5-pyridinedicarboxylate

Product 1

HCID 9950812HCID 9950812, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

2.78 g (0.008 mol) of diethyl 2,6-dimethyl-4-(4-fluorophenyl)-1,4-dihydro-pyridine-3,5-dicarboxylate dissolved in 25 ml of 1,2-dimethoxyethane, and 0.30 g (0.01 mol) of 80% strength sodium hydride and, after 30 min, 1.43 g (0.01 mol) of methyl iodide are added. The mixture is stirred at room temperature for 3 hours, neutralized with dilute hydrochloric acid and evaporated in vacuo. The residue is purified by chromatography on silica gel (methylene chloride).

Workup

  1. customevaporated in vacuo
  2. customThe residue is purified by chromatography on silica gel (methylene chloride)

Sources & evidence

ORD record
ord-fa4bd839c57f459eaae370e814cbdf39
Source dataset
uspto-grants-1993_08
Patent number
US05234935

Reaction notes

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