Hydrochloric Acid → HCID 11260476, compound

HRID 225447Notes

Reaction equation

HRID 225447 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:9]2[C:13]3[N:14]=[C:15]([CH3:26])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]4)[C:12]=3[S:11][C:10]=2[CH3:27])=[C:4]([CH3:28])[CH:3]=1.CCO.[ClH:32]>CCOC(C)=O>[ClH:32].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:9]2[C:13]3[N:14]=[C:15]([CH3:26])[N:16]=[C:17]([N:18]4[CH2:19][CH2:20][CH:21]([CH2:24][OH:25])[CH2:22][CH2:23]4)[C:12]=3[S:11][C:10]=2[CH3:27])=[C:4]([CH3:28])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 11260477HCID 11260477, compound

Product 1

HCID 11260476HCID 11260476, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a suspension of {1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,6-dimethyl-thieno[3,2-d]pyrimidin-4-yl]-piperidin-4-yl}-methanol (568 mg) in a mixture (1:1) of EtOH and EtOAc (2 mL) was added 4 M HCl in EtOAc (0.37 mL) under ice-cooling. The mixture was stirred overnight to afford a white crystal. The crystal was collected by filtration to give the title compound (532 mg).

Workup

  1. temperaturecooling
  2. customto afford a white crystal
  3. filtrationThe crystal was collected by filtration

Sources & evidence

ORD record
ord-ff7dac3fad57486794421679fe055e49
Source dataset
uspto-grants-2009_07
Patent number
US07557111B2

Reaction notes

Loading…