Pyrazole → HCID 19742629, compound

HRID 2254521Notes

Reaction equation

HRID 2254521 reaction equation
[I-:1].Cl[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N+:4]=1[CH3:9].[NH:10]1[CH:14]=[CH:13][CH:12]=[N:11]1.C(N(C(C)C)CC)(C)C>C(#N)C>[I-:1].[CH3:9][N+:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1

Participants

5

Reactant 3

HCID 1048PyrazoleHCID 81531DiisopropylethylamineHCID 1670692-Chloro-1-methylpyridinium iodide

Product 1

HCID 19742629HCID 19742629, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-Chloro-1-methylpyridinium iodide (5.0 g), pyrazole (1.3 g) and diisopropylethylamine (2.5 g) were added to acetonitrile (50 ml) and the mixture refluxed for 3.5 hours. The acetonitrile was removed and the residue dissolved in hot ethanol. The solution was left in the refrigerator overnight. The product was collected by filtration Yield, 1.73 g; mp 129°-130° C.

Workup

  1. temperaturethe mixture refluxed for 3.5 hours
  2. customThe acetonitrile was removed
  3. dissolutionthe residue dissolved in hot ethanol
  4. filtrationThe product was collected by filtration
  5. customYield

Sources & evidence

ORD record
ord-d2fed9b04a9948d18aa70d021b621d51
Source dataset
uspto-grants-1993_08
Patent number
US05236822

Reaction notes

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