Sodium Hydroxide → HCID 19742681, compound

Temperature

150 °C

10-Dodecyn-1-amine hydrochloride (2.0 g, 9.2 mmol) and 1 ml THF were added to 30 ml diglyme. Lithium aluminum hydride (2 g, 53 mmol) were added and the mixture was heated at 150° C. for 96 hours. The mixture was cooled and 15% aqueous NaOH was added and the mixture was extracted with Et2O. The extracts were dried over Na2SO4, filtered, and the solvent was evaporated. The residue was chromatographed on silica gel eluting with CH2Cl2 -MeOH-NH4OH (150:90:1) to obtain an oil. The oil was dissolved in Et2O, 9 ml 1N HCl-dioxane solution were added, and solvent was evaporated to leave the title compound (0.9 g, 45% yield): C12H25N·HCl (219.80); 1H-NMR (CDCl3) δ8.3 (br s,3), 5.41 (m,2), 2.99 (m,2), 1.97 (m,2), 1.8 (m,2), 1.64 (d,3), 1.4-1.2 (m,12). Anal. calcd.: C, 65.57; H, 11.92; N, 6.37; found: C, 65.56; H, 11.55; N, 6.15.

1. temperatureThe mixture was cooled
2. extractionthe mixture was extracted with Et2O
3. dry with materialThe extracts were dried over Na2SO4
4. filtrationfiltered
5. customthe solvent was evaporated
6. customThe residue was chromatographed on silica gel eluting with CH2Cl2 -MeOH-NH4OH (150:90:1)
7. customto obtain an oil
8. customsolvent was evaporated

ORD record

ord-4ec80f289a734c8088a4762ae2846c16

Source dataset

uspto-grants-1993_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05236900