Phosphorus oxychloride → HCID 57753077, compound

HRID 225464Notes

Reaction equation

[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([C:9]2[NH:14][C:13]3[CH:15]=[CH:16][S:17][C:12]=3[C:11](=O)[N:10]=2)=[C:4]([F:19])[CH:3]=1.P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:11]1[C:12]2[S:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:9]([C:5]2[CH:6]=[C:7]([F:8])[C:2]([Cl:1])=[CH:3][C:4]=2[F:19])[N:10]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178517534HCID 178517534, compound

Product 1

HCID 57753077HCID 57753077, compound

Conditions

Temperature: 90 °C

Procedure

A mixture of 2-(4-chloro-2,5-difluorophenyl)thieno[3,2-d]pyrimidine-4(1H)-one and phosphorus oxychloride was stirred for four hours at 90° C. to give 4-chloro-2-(4-chloro-2,5-difluorophenyl)thieno[3,2-d]pyrimidine.

Sources & evidence

ORD record: ord-f1e93a1b59a64712a0691c7aeb14cd6f
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557112B2

Reaction notes

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