反应详情

A solution of 4.5 g of 1,1-ethylenedioxy-4-(1-pentynyl)cyclohexane in 54 ml of tetrahydrofuran was treated dropwise with about 50 ml of pre-condensed ammonia in a sulphonation flask equipped with magnetic stirrer. The mixture was subsequently treated portionwise at -78° C. within 7 hours with 1.3 g of sodium. 1.5 hours after the last addition the ammonia was evaporated off and the reaction mixture was neutralized with 25% hydrochloric acid and left to stand overnight. Thereafter, the reaction mixture was partitioned three times in water/diethyl ether. The aqueous phases were back-extracted with diethyl ether. The organic phases were dried over magnesium sulphate and freed from solvent on a rotary evaporator. The pale yellow liquid obtained (3.8 g) was treated with 200 ml of acetone and 0.1 ml of concentrated sulphuric acid. The mixture was heated to reflux for 10 minutes, then treated with water and freed from acetone on a rotary evaporator. The residue was partitioned three times in methylene chloride/water. The aqueous phases were back-extracted with methylene chloride. The organic phases were dried over magnesium sulphate and evaporated. Chromatographic separation of the residual, yellow liquid (3.5 g) on silica gel with ethyl acetate/petroleum ether (vol. 7:93) gave 3.0 g (83.5%) of 4-(1E-pentenyl)cyclohexanone as a pale yellow liquid.

1. customequipped with magnetic stirrer
2. customwas evaporated off
3. waitleft
4. customThereafter, the reaction mixture was partitioned three times in water/diethyl ether
5. extractionThe aqueous phases were back-extracted with diethyl ether
6. dry with materialThe organic phases were dried over magnesium sulphate
7. customfreed from solvent on a rotary evaporator
8. customThe pale yellow liquid obtained (3.8 g)
9. temperatureThe mixture was heated
10. temperatureto reflux for 10 minutes
11. customfreed from acetone on a rotary evaporator
12. customThe residue was partitioned three times in methylene chloride/water
13. extractionThe aqueous phases were back-extracted with methylene chloride
14. dry with materialThe organic phases were dried over magnesium sulphate
15. customevaporated
16. customChromatographic separation of the residual, yellow liquid (3.5 g) on silica gel with ethyl acetate/petroleum ether (vol. 7:93)