反应详情

A mixture of 3-bromomethylbenzoic acid (4.30 g, 20 mmol), piperazin-2-one (2.0 g, 20 mmol) and powdered potassium carbonate (2.76 g, 20 mmol) in methanol (50 mL) is stirred for 17 hours at room temperature. The resulting mixture is filtered and the solvent is evaporated off under reduced pressure to give a residue which is treated with hydrochloric acid (80 mL of 0.25 M) and stirred for 5 min. The precipitated product is filtered, washed with water, dried and recrystallised from methanol to give the title compound as a cream crystalline solid.

1. filtrationThe resulting mixture is filtered
2. customthe solvent is evaporated off under reduced pressure
3. customto give a residue which
4. stirringstirred for 5 min
5. filtrationThe precipitated product is filtered
6. washwashed with water
7. customdried
8. customrecrystallised from methanol