Pyridine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 2255083Notes

Reaction equation

HRID 2255083 reaction equation
ClC([O-])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1COCC1>[CH2:8]1[CH2:9][CH2:10][N:5]2[C:10](=[N:5][CH2:6][CH2:7][CH2:8]2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 21226386Carbonochloridate

Product 1

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compounds of Formula (I) wherein R1 is --SO2NHCO2R23 may be prepared by reacting an appropriate chloroformate with the sulfonamide (43) in pyridine or in the presence of DBU in THF to afford the desired compound (45), as outlined in Scheme 19. ##STR120##

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-b90be9790dea4a399517cd52927b5f0a
Source dataset
uspto-grants-1993_08
Patent number
US05238942

Reaction notes

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