Anisole → HCID 131718085, compound

HRID 2255096Notes

Reaction equation

HRID 2255096 reaction equation
C1(OC)C=CC=CC=1.[CH:9]([C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[NH:18][CH:17]([CH2:22][CH2:23][CH3:24])[N:16]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[S:38]([NH:41]C(C)(C)C)(=[O:40])=[O:39])=[CH:28][CH:27]=1)[C:15]2=[O:46])([CH3:11])[CH3:10]>FC(F)(F)C(O)=O>[CH:9]([C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[NH:18][CH:17]([CH2:22][CH2:23][CH3:24])[N:16]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[S:38]([NH2:41])(=[O:40])=[O:39])=[CH:28][CH:27]=1)[C:15]2=[O:46])([CH3:10])[CH3:11]

Participants

4

Reactant 2

HCID 7519AnisoleHCID 131718086HCID 131718086, compound

Product 1

HCID 131718085HCID 131718085, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Anisole is added to a stirred solution of the compound from Step 1 (0.554 mmol) in trifluoroacetic acid (6 ml) under nitrogen at room temperature. The solution is stirred at room temperature for 8 h then the solvent removed in vacuo. Flash chromatography affords the titled product.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-d6ffb8b5051f40e4be6cb5c284750ff1
Source dataset
uspto-grants-1993_08
Patent number
US05238942

Reaction notes

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