HCID 19741716, compound → HCID 178511452, compound

HRID 2255121Notes

Reaction equation

HRID 2255121 reaction equation
C1(C([NH:9][CH:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]3[NH:26][N:25]([Sn](CCCC)(CCCC)CCCC)[NH:24][N:23]=3)=[C:17]([O:40]C(C3C=CC=CC=3)=O)[CH:16]=2)[C:11]([O:13]C)=[O:12])=O)C=CC=CC=1>Cl>[NH2:9][CH:10]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]2[NH:26][N:25]=[N:24][N:23]=2)=[C:17]([OH:40])[CH:16]=1)[C:11]([OH:13])=[O:12]

Participants

3

Reactant 1

HCID 19741716HCID 19741716, compound

Product 1

HCID 178511452HCID 178511452, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl α-[(phenylcarbonyl)amino]-3-[(phenylcarbonyl)-oxy]-4-[[2-(tributylstannyl)-1H-tetrazol-5-yl]methyl]benzeneacetate from the Preparation 11 above in 6N HCl is heated at reflux until consumed. The reaction mixture is cooled to room temperature and extracted with 1:1 ether/toluene. The aqueous phase is concentrated to give the product of α-amino-3-hydroxy-4-(1H-tetrazol-5-ylmethyl)-benzeneacetic acid.

Workup

  1. temperatureis heated
  2. temperatureat reflux
  3. customuntil consumed
  4. extractionextracted with 1:1 ether/toluene
  5. concentrationThe aqueous phase is concentrated

Sources & evidence

ORD record
ord-3e44ed2d4bad46569f44d8d43928cb84
Source dataset
uspto-grants-1993_08
Patent number
US05238958

Reaction notes

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