2-Chlorophenol → 2-Chloroanisole

HRID 2255357Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[C:9]([O-])(=O)CC(CC([O-])=O)(C([O-])=O)O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9]

Participants

Reactant 2

HCID 72452-Chlorophenol

HCID 31348Citrate

Product 1

HCID 130112-Chloroanisole

Procedure

A 2 mM solution of 2-chlorophenol containing 1.23 mM chloromethane and buffered at pH 4.0 with 20 mM citrate buffer was incubated with 0.035 g of fungal mycelium (Phellinus pomaceus, NCWRF. FPRL 33A or CBS 137.42) at 25° C. for 12 h. 2-chloroanisole was formed at a rate of 16 nanomoles/g fungal mycelium/hour.

Sources & evidence

ORD record: ord-3238b8be46c84d99b30a5412db0036f7
Source dataset: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05240836

Reaction notes

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