Triethylamine → Ethyl 2,6-dimethyl-4-morpholinepropionate

HRID 2255369Notes

Reaction equation

HRID 2255369 reaction equation
[CH3:1][CH:2]1[O:7][CH:6]([CH3:8])[CH2:5][NH:4][CH2:3]1.Cl[CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:8][CH:6]1[O:7][CH:2]([CH3:1])[CH2:3][N:4]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:5]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 69341Ethyl 3-chloropropionateHCID 1108622,6-Dimethylmorpholine

Product 1

HCID 98759Ethyl 2,6-dimethyl-4-morpholinepropionate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This intermediate (26.0 g.) was prepared using the procedure described in Example 4a except using 24.5 ml. (0.2 mole) of 2,6-dimethylmorpholine, 19.2 ml. (0.20 mole) of ethyl 3-chloropropionate, and 30.3 ml. (0.22 mole) of triethylamine in 60 ml. of toluene and was isolated as a colorless liquid boiling 88°-88.5° C. at 5 mm of Hg.

Workup

  1. customThis intermediate (26.0 g.) was prepared
  2. customboiling 88°-88.5° C. at 5 mm of Hg

Sources & evidence

ORD record
ord-ed5d39c1d70e4851a2dfec9950667bee
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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