Triethylamine → HCID 13191868, compound

HRID 2255375Notes

Reaction equation

HRID 2255375 reaction equation
[CH3:1][CH:2]1[O:7][CH:6]([CH3:8])[CH2:5][NH:4][CH2:3]1.Br[CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:8][CH:6]1[O:7][CH:2]([CH3:1])[CH2:3][N:4]([CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:5]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 76300Ethyl 4-bromobutyrateHCID 1108622,6-Dimethylmorpholine

Product 1

HCID 13191868HCID 13191868, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This intermediate (37.8 g.) was prepared using the procedure described in Example 4a except using 24.5 ml. (0.2 mole) of 2,6-dimethylmorpholine, 28.6 ml. (0.2 mole) of ethyl 4-bromobutyrate, 30.3 ml. (0.2 mole) of triethylamine, and 60 ml. of toluene and was isolated as a colorless liquid boiling 96.5°-97° C. at 4 mm of Hg.

Workup

  1. customThis intermediate (37.8 g.) was prepared
  2. customboiling 96.5°-97° C. at 4 mm of Hg

Sources & evidence

ORD record
ord-77210b53cf0a4db3a083103739e562c2
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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