Toluene → HCID 19738034, compound

HRID 2255381Notes

Reaction equation

HRID 2255381 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH:17]([CH3:19])[O:16][CH:15]([CH3:20])[CH2:14]1.[H-].[Na+].[Cl:23][C:24]1[CH:32]=[CH:31][C:27]([CH2:28][C:29]#[N:30])=[CH:26][CH:25]=1.C1(C)C=CC=CC=1>CN(C=O)C>[Cl:23][C:24]1[CH:32]=[CH:31][C:27]([CH:28]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH:17]([CH3:19])[O:16][CH:15]([CH3:20])[CH2:14]2)[C:29]#[N:30])=[CH:26][CH:25]=1

Participants

6

Reactant 4

HCID 1140TolueneHCID 24758Sodium hydrideHCID 2415824-Chlorobenzyl cyanideHCID 19738027HCID 19738027, compound

Product 1

HCID 19738034HCID 19738034, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This intermediate (900 mg.) was prepared using the procedure described in Example 2a except using 3.9 g. (0.013 mole) of 4-(11-chloroundecyl)-2,6-dimethylmorpholine, 0.62 g. (0.014 mole) of sodium hydride, 1.97 g. (0.013 mole) of 4-chlorobenzyl cyanide, and 75 ml. of a 2 to 1 mixture of toluene and DMF.

Workup

  1. customThis intermediate (900 mg.) was prepared

Sources & evidence

ORD record
ord-cd394cd9aae74b41988c4803e8d8d91b
Source dataset
uspto-grants-1993_08
Patent number
US05240925

Reaction notes

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