Hydrochloric Acid → HCID 19738006, compound

HRID 2255502Notes

Reaction equation

HRID 2255502 reaction equation
[CH2:1]([N:3]([CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[S:4]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)(=[O:6])=[O:5])[CH3:2].C([Li])CCC.[S:25](=[O:27])=[O:26].[NH2:28]OS(O)(=O)=O.[ClH:34]>>[ClH:34].[CH2:1]([N:3]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)[S:4]([C:7]1[S:8][C:9]([S:25]([NH2:28])(=[O:27])=[O:26])=[CH:10][CH:11]=1)(=[O:5])=[O:6])[CH3:2]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 76284hydroxylamine-O-sulfonic acidHCID 19737943HCID 19737943, compoundHCID 178418339Butyllithium

Product 1

HCID 19738006HCID 19738006, compound

Procedure

The product from Step A (2.2 g, 7.24 mmol) was treated sequentially with n-butyllithium, sulfurdioxide, hydroxylamine-O-sulfonic acid and ethanolic HCl in much the same way as described in Example 4 to furnish the desired product as a hygroscopic white solid: mp 80°-85° C.

Sources & evidence

ORD record
ord-7c6239c25df54b94a04193c9cb1ce883
Source dataset
uspto-grants-1993_08
Patent number
US05240923

Reaction notes

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