反应详情

A solution of 13.5 mmol N-BOC-3-pyrrolidone and 13.5 mmol N,N-dimethylformamide-dimethylacetal in 50 ml N,N-dimethylformamide was hold overnight at 60° C. The reaction mixture was quenched by addition of 50 ml water and extracted 3 times with ethyl acetate. The extract was dried over magnesium sulfate and concentrated to give the crude title compound as a yellowish oil. Yield=90%. MS (m/e): 241.4 ([M+H]+, 100%).

1. customThe reaction mixture was quenched by addition of 50 ml water
2. extractionextracted 3 times with ethyl acetate
3. dry with materialThe extract was dried over magnesium sulfate
4. concentrationconcentrated