Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 2255687Notes

Reaction equation

HRID 2255687 reaction equation
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19100972HCID 19100972, compound

Product 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate, extracted ten times using 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

Workup

  1. extractionextracted ten times
  2. dry with materialdried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-62c3a6587ea8476698bf2c6a726ec6ea
Source dataset
uspto-grants-1993_08
Patent number
US05241076

Reaction notes

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