1-Iodopropane → 2-(Propylthio)pyrimidine-4,6-diol

HRID 2255897Notes

Reaction equation

HRID 2255897 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([SH:9])[N:3]=1.[CH2:10](I)[CH2:11][CH3:12]>[OH-].[K+]>[CH2:10]([S:9][C:4]1[N:5]=[C:6]([OH:8])[CH:7]=[C:2]([OH:1])[N:3]=1)[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 336431-IodopropaneHCID 178516656HCID 178516656, compound

Product 1

HCID 1784608102-(Propylthio)pyrimidine-4,6-diol

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

To a solution of 4,6-dihydroxy-2-mercaptopyrimidine (100 g) in potassium hydroxide (2.5N, 571 ml) was added propyl iodide (76.8 ml) and the whole was stirred for 4 days. The solution was acidified to pH 2-3 and filtered to afford the sub-title compound (15 g).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-c39d40f5d3564ea99a87b7a10abbfef6
Source dataset
uspto-grants-1997_08
Patent number
US05654285

Reaction notes

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