Aminoethylpiperazine → HCID 10538710, compound

HRID 2255998Notes

Reaction equation

HRID 2255998 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.C(O[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20])C>CC#N>[N+:19]([C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:13]=1[NH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([O-:21])=[O:20]

Participants

4

Reactant 2

HCID 8795AminoethylpiperazineHCID 3563054-Ethoxy-3-nitropyridine

Product 1

HCID 10538710HCID 10538710, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 1-(2-aminoethyl)piperazine and 4-ethoxy-3-nitropyridine in CH3CN was heated at reflux for 40 hours. The reaction mixture was cooled to ambient temperature and concentrated to give 3-nitro-4-[2-(piperazine-1-yl)ethyl]aminopyridine which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 40 hours
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b47c83b98d9744ce97bd72ae13e28fcb
Source dataset
uspto-grants-1997_08
Patent number
US05654305

Reaction notes

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