Hydrochloric Acid → 5-Methyl-6-morpholin-4-yl-2,3-dihydro-1H-isoindole hydrochloride

HRID 225612Notes

Reaction equation

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[C:13]([CH3:17])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24]>>[ClH:24].[CH3:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH2:9][NH:8][CH2:16]2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 577533775-Methyl-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester

Product 1

HCID 688228265-Methyl-6-morpholin-4-yl-2,3-dihydro-1H-isoindole hydrochloride

Procedure

Prepared in analogy to Example A3(e) from 5-methyl-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Brown solid. MS (m/e): 219.3 ([M+H]+, 100%).

Sources & evidence

ORD record: ord-bc1313b18a66428083130e92c47740f2
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557114B2

Reaction notes

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