Piperidine → 4-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine

HRID 2256194Notes

Reaction equation

HRID 2256194 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[NH:5][C:6]1[C:7]2[CH:15]=[C:14](F)[N:13]=[CH:12][C:8]=2[N:9]=[CH:10][N:11]=1.[NH:20]1[CH2:25]CCC[CH2:21]1>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[NH:5][C:6]1[C:7]2[CH:15]=[C:14]([N:20]([CH3:25])[CH3:21])[N:13]=[CH:12][C:8]=2[N:9]=[CH:10][N:11]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 5328260N-(3-bromophenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine

Product 1

HCID 53282614-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Treatment of 4-(3-bromoanilino)-6-fluoropyrido[3,4-d]pyrimidine (see a previous experimental) at 100° C. in a pressure vessel with piperidine in ethanol gives 4-(3-bromoanilino)-6-dimethylaminopyrido[3,4-d]pyrimidine.

Workup

  1. customat 100° C.

Sources & evidence

ORD record
ord-32d52bf1d2b8467e978b40f466acb6ad
Source dataset
uspto-grants-1997_08
Patent number
US05654307

Reaction notes

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