Trifluoroacetic acid → 5-Cyclopropyl-6-morpholin-4-yl-2,3-dihydro-1H-isoindole trifluoroacetate

HRID 225626Notes

Reaction equation

HRID 225626 reaction equation
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[C:13]([CH:17]3[CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH:17]1([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][C:12]=2[N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[CH2:9][NH:8][CH2:16]3)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 577533705-Cyclopropyl-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Product 1

HCID 688218965-Cyclopropyl-6-morpholin-4-yl-2,3-dihydro-1H-isoindole trifluoroacetate

Procedure

Prepared in analogy to Example A2(c) from 5-cyclopropyl-6-morpholin-4-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown solid. MS (m/e): 245.4 ([M+H]+, 100%).

Sources & evidence

ORD record
ord-d21c596f3487448aa689b62ccf333f11
Source dataset
uspto-grants-2009_07
Patent number
US07557114B2

Reaction notes

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