Thiazole → HCID 22220633, compound

HRID 2256780Notes

Reaction equation

HRID 2256780 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[Br:6][CH2:7][C:8]([O:10][CH3:11])=[O:9]>C(O)C>[Br-:6].[CH3:11][O:10][C:8](=[O:9])[CH2:7][N+:3]1[CH:4]=[CH:5][S:1][CH:2]=1

Participants

4

Reactant 2

HCID 9256ThiazoleHCID 60984Methyl bromoacetate

Product 1

HCID 22220633HCID 22220633, compoundYield 66.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Thiazole, (850 mg, 10 mmol), methyl bromoacetate (1.52, 10 mmol) and absolute ethanol (50 ml) were refluxed for 2 hours. On cooling, the salt separated and was recrystallized from absolute ethanol to give the title compound (1.59 g), m.p. 189°-190° C. (dec).

Workup

  1. temperatureOn cooling
  2. customthe salt separated
  3. customwas recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-171ae26f49934b0baf469e3a0e9a7aad
Source dataset
uspto-grants-1997_08
Patent number
US05656261

Reaction notes

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