2-Nitroimidazole → N-(4-Methylpent-3-en-1-yl)-2-nitroimidazole

HRID 2256783Notes

Reaction equation

HRID 2256783 reaction equation
Br[CH2:2][CH2:3][CH:4]=[C:5]([CH3:7])[CH3:6].[N+:8]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)([O-:10])=[O:9].C(=O)([O-])[O-].[K+].[K+]>>[CH3:6][C:5]([CH3:7])=[CH:4][CH2:3][CH2:2][N:12]1[CH:13]=[CH:14][N:15]=[C:11]1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 107012-NitroimidazoleHCID 11430Potassium CarbonateHCID 1375215-Bromo-2-methyl-2-pentene

Product 1

HCID 15186012N-(4-Methylpent-3-en-1-yl)-2-nitroimidazole

Procedure

5-Bromo-2-methyl-2-pentene (15 g, 0.092 mol) was added to a slurry of 2-nitroimidazole (10.4 g, 0.092 mol) and potassium carbonate (12.7 g, 0.092 mol) and refluxed for 24 hrs. Acetone was removed on a rotary evaporator and the residue was purified by column chromatography.

Workup

  1. temperaturerefluxed for 24 hrs
  2. customAcetone was removed on a rotary evaporator
  3. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-a2276d97f4c24016a52215907da0cf84
Source dataset
uspto-grants-1997_08
Patent number
US05656254

Reaction notes

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