Hydrochloric Acid → 1-Ethoxy-3-chloro-3-methyl-2-nitrosobutane
Reaction equation
[ClH:1].[N:2]([O:4]CCC(C)C)=O.[CH2:10]([O:12][CH2:13][CH:14]=[C:15]([CH3:17])[CH3:16])[CH3:11]>>[CH2:10]([O:12][CH2:13][CH:14]([N:2]=[O:4])[C:15]([Cl:1])([CH3:17])[CH3:16])[CH3:11]Participants
4
Conditions
- Temperature
- 5 °C
Procedure
Concentrated HCl was added to a cooled (0°-5° C.) solution of isoamyl nitrite (14.0 g, 120 mmol) and 1-ethoxy-3-methyl-2-butene (6.84 g, 60 mmol). The temperature was maintained below 5° C. during the addition and the reaction mixture was stirred at 5° C. for an additional 30 min. The product was filtered and washed with a cold (-20° C.) 1:1 mixture of ethanol and ether. The solid was further washed with ether to afford a white solid.
Workup
- temperatureThe temperature was maintained below 5° C. during the addition
- filtrationThe product was filtered
- washwashed with a cold (-20° C.) 1:1 mixture of ethanol and ether
- washThe solid was further washed with ether
- customto afford a white solid
Sources & evidence
- ORD record
- ord-0130082136c44360a73c9d01e0a0628e
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05656254
Reaction notes
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