Acetic Anhydride → HCID 13686733, compound

HRID 2256807Notes

Reaction equation

HRID 2256807 reaction equation
[OH:1][N:2]1[C:11](=[O:12])[CH:10]2[CH:5]([CH:6]3[CH2:13][CH:9]2[CH:8]=[CH:7]3)[C:3]1=[O:4].C(N(CC)CC)C.[C:21](OC(=O)C)(=[O:23])[CH3:22]>C(Cl)(Cl)Cl>[C:21]([O:1][N:2]1[C:11](=[O:12])[CH:10]2[CH:5]([CH:6]3[CH2:13][CH:9]2[CH:8]=[CH:7]3)[C:3]1=[O:4])(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 895293a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione

Product 1

HCID 13686733HCID 13686733, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N-Hydroxy-norborn-5-ene-2,3-dicarboximide (17.92 g, 0.1 mole) is largely dissolved in 100 mL chloroform and 21 mL (0.15 moles) triethylamine, followed by adding 19 mL (0.2 moles) acetic anhydride at 0° C. with stirring. After stirring for 2 hours at room temperature, the solvent is largely removed, the residue is mixed with water and the precipitate is filtered off.

Workup

  1. stirringAfter stirring for 2 hours at room temperature
  2. customthe solvent is largely removed
  3. additionthe residue is mixed with water
  4. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-11bac359b9ce4ad5bae21f369427da61
Source dataset
uspto-grants-1997_08
Patent number
US05656601

Reaction notes

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