HCID 22874412, compound → HCID 22874407, compound

HRID 2256838Notes

Reaction equation

HRID 2256838 reaction equation
C([O:5][C:6]([CH2:8][C@@H:9]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[C:6]([CH2:8][C@@H:9]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])([OH:7])=[O:5]

Participants

3

Reactant 1

HCID 22874412HCID 22874412, compound

Product 1

HCID 22874407HCID 22874407, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of benzyl (2R)-2-t-butoxycarbonylmethyl-4-methylvalerate (3.40 g) in TFA (60 ml) was stirred for 1 hour under ice-bath cooling. Evaporation of TFA gave benzyl (2R)-2-carboxymethyl-4-methylvalerate (2.72 g) as an oil.

Workup

  1. temperaturecooling
  2. customEvaporation of TFA

Sources & evidence

ORD record
ord-000c91d9473a45fa8e4a2d200d0dd861
Source dataset
uspto-grants-1997_08
Patent number
US05656604

Reaction notes

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