Trifluoroacetic acid → HCID 22943378, compound

HRID 2257109Notes

Reaction equation

HRID 2257109 reaction equation
[CH2:1]([O:4][C:5]([NH:7][C:8]1[C:9](=[O:20])[N:10]([CH2:14][C:15]([O:17]CC)=[O:16])[CH:11]=[CH:12][CH:13]=1)=[O:6])[CH:2]=[CH2:3].FC(F)(F)C(O)=O>ClCCl.C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]([NH:7][C:8]1[C:9](=[O:20])[N:10]([CH2:14][C:15]([OH:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)=[O:6])[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57242741HCID 57242741, compound

Product 1

HCID 22943378HCID 22943378, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

The compound of example 60 (1.00 g) is treated with 50% trifluoroacetic acid in dichloromethane (10 mL) for 1 hour at 0° C., and 3 hours at room temperature. The solution is diluted with toluene (50 mL) and the solvent is removed in vacuo to afford the title compound.

Workup

  1. custom3 hours
  2. customat room temperature
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-0be03d1d67594579b9e499ae0f644ffa
Source dataset
uspto-grants-1997_08
Patent number
US05656645

Reaction notes

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