反应详情

温度

70 °C

To 30.7 mmol 2-Iodo-5-methanesulfonyl-benzoic acid in 250 ml THF was added 33.7 mmol CDI and the mixture was heated at 70° C. for 1 h. Methanol (12.4 ml) was then added and the mixture was heated at 70° C. for a further 1 h. The mixture was then cooled to room temperature and concentrated in vacuo. The residue was chromatographed over SiO2 (ethyl acetate/dichloromethane 4:1) to afford the title compound (86%) as a white crystalline solid.

1. temperaturethe mixture was heated at 70° C. for a further 1 h
2. temperatureThe mixture was then cooled to room temperature
3. concentrationconcentrated in vacuo
4. customThe residue was chromatographed over SiO2 (ethyl acetate/dichloromethane 4:1)