反应详情

温度

60 °C

To 3.44 mmol 4-Methanesulfonyl-biphenyl-2-carboxylic acid methyl ester in 5 ml THF was added 37.9 mmol 5 M aq. NaOH solution and the mixture was heated at 60° C. for 16 h. The mixture was then cooled to RT, acidified to pH 1 with conc. hydrochloric acid, and extracted 3 times with ethyl acetate. The combined organic phases were dried with Na2SO4. Evaporation in vacuo afforded the title compound (95%) as an off-white crystalline solid. MS (m/e): 275.1 (M−H, 100%)

1. temperatureThe mixture was then cooled to RT
2. extractionextracted 3 times with ethyl acetate
3. dry with materialThe combined organic phases were dried with Na2SO4
4. customEvaporation in vacuo