Hydrochloric Acid → (R)-8-Fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride

HRID 2257331Notes

Reaction equation

HRID 2257331 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14][CH3:15])[CH2:7]2.[ClH:22]>CCOCC>[ClH:22].[F:1][C:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]2[C:11]=1[O:10][CH2:9][C@H:8]([N:12]([CH:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[CH2:13][CH2:14][CH3:15])[CH2:7]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53847727HCID 53847727, compound

Product 1

HCID 67703430(R)-8-Fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

(R)-8-Fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman (180 mg, 0.6 mmol) was dissolved in ether. HCl in ether was added to precipitate the HCl-salt, and gave after drying 200 mg of (R)-8-fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride as a white powder. Mp: 80°-100° C. (sinters).

Workup

  1. customto precipitate the HCl-salt
  2. customgave
  3. dry with materialafter drying 200 mg of (R)-8-fluoro-5-hydroxy-3-(N-3-pentyl-N-n-propylamino)chroman hydrochloride as a white powder

Sources & evidence

ORD record
ord-27070449cdf743a39194330a23c37fff
Source dataset
uspto-grants-1997_08
Patent number
US05656657

Reaction notes

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