Benzaldehyde → HCID 69061886, compound

HRID 225771Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH:16]1[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[N:7]([CH3:29])[C:6]2=[O:30].[CH:31](=O)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([CH:15]1[CH2:20][CH2:19][N:18]([CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:17][CH:16]1[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[N:7]([CH3:29])[C:6]2=[O:30]

Participants

Reactant 2

HCID 240Benzaldehyde

HCID 69069532HCID 69069532, compound

Product 1

HCID 69061886HCID 69061886, compound

Procedure

Formula I where U—V is —CReRf—CRgRh—N(R6)—; R1, R4, Rb and Rc to Rh are H; R2 and R3 are methoxy; R5 is methyl; and Ra is phenethyl; and R6 is benzyl: By following the procedure described in Example 3, substituting 3-benzyl-7-chloro-1-(pyrrolidine-2-carbonyl)-2,3-dihydro-1H-quinazoline-4-one with 6,7-dimethoxy-2-[3-phenethyl-piperidin-4-yl]-3-methyl-3H-quinazolin-4-one, and substituting p-tolualdehyde with benzaldehyde, there is obtained 6,7-dimethoxy-2-[1-benzyl-3-phenethyl-piperidin4-yl]-3-methyl-3H-quinazolin-4-one.

Sources & evidence

ORD record: ord-5896d1c078e14908ad5f403a4593e3c5
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557115B2

Reaction notes

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