Triethylamine → HCID 86594852, compound

HRID 225775Notes

Reaction equation

HRID 225775 reaction equation
[CH3:1][C:2]1[O:6][C:5]([CH:7]=[CH:8][CH2:9][CH2:10][CH3:11])=[N:4][C:3]=1[CH2:12][CH2:13][OH:14].C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(OCC)(=O)C>C(Cl)Cl>[CH3:22][S:23]([O:14][CH2:13][CH2:12][C:3]1[N:4]=[C:5](/[CH:7]=[CH:8]/[CH2:9][CH2:10][CH3:11])[O:6][C:2]=1[CH3:1])(=[O:25])=[O:24]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 31297Methanesulfonyl chlorideHCID 69060333HCID 69060333, compound

Product 1

HCID 86594852HCID 86594852, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[5-Methyl-2-(1-penten-1-yl)oxazol-4-yl]ethanol (1.03 g) was dissolved in methylene chloride (10 ml), and triethylamine (1.03 ml) was added. Methanesulfonyl chloride (0.41 ml) was added dropwise at 0° C., and the mixture was stirred at room temperature for 30 min. Ethyl acetate (100 ml) was added, and the mixture was washed with 10% aqueous citric acid solution (100 ml) and then with saturated brine (100 ml), and dried (Na2SO4). The solvent was evaporated under reduced pressure to give the title compound (1.1 g).

Workup

  1. washthe mixture was washed with 10% aqueous citric acid solution (100 ml)
  2. dry with materialwith saturated brine (100 ml), and dried (Na2SO4)
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-83e7b166f5164704bb224ad53d2b49db
Source dataset
uspto-grants-2009_07
Patent number
US07557123B2

Reaction notes

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