Iodoethane → 1-Ethoxy-3-fluorobenzene

HRID 2257802Notes

Reaction equation

HRID 2257802 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH2:9](I)[CH3:10].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:9]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH3:10]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 97433-FluorophenolHCID 11430Potassium Carbonate

Product 1

HCID 1363011-Ethoxy-3-fluorobenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

3-Fluorophenol (20.0 g, 178.4 mmol), ethyl iodide (83.5 g, 535.2 mmol) and K2CO3 (49.3 g, 356.8 mmol) in 250 ml of acetone were stirred at 50° C. overnight. The mixture was filtered and evaporated to give 1-ethoxy-3-fluorobenzene.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-a90f3eea35354721ad80cadf65b35cff
Source dataset
uspto-grants-1997_08
Patent number
US05658907

Reaction notes

Loading…