Methyl iodide → HCID 178436410, compound

Temperature

-78 °C

To a suspension of 1-hydroxy-6-methylpyridine-3-carbonitrile (12.24 g, 0.91 mole) in tetrahydrofuran (100 mL) cooled to -78° C. under a nitrogen atmosphere was added dropwise lithium diisopropylamide (100 mL of a 2.0M solution in heptane/tetrahydrofuran/ethylbenzene, 0.20 mole). After the addition was complete, the solution was stirred in an ice bath for 2 hours. Iodomethane (6.25 mL, 0.10 mmol) was added, and the reaction mixture was stirred for an additional 2.5 hours at 0° C. and 30 minutes at room temperature. Water (300 mL) and 1.0N NaOH 50 mL) were added. The aqueous solution was washed with ethyl acetate (150 mL), acidified with 1.0N sodium bisulfate to pH 4, and extracted with 10% methanol/ethyl acetate twice (500 mL total). Sodium chloride was added to the aqueous layer, and the solution was extracted with 10% isopropanol/ethyl acetate twice (500 mL total). The combined organic layers were washed with brine, dried over magnesium sulfate and the solvent removed under reduced pressure. The residue was recrystallized from methanol/isopropanol to give the title compound (7.56 g) as orange needles in 56% yield. Rf=0.26 (silica gel, 10% isopropanol/chloroform). m.p. 235°-240° C. (decomp).

1. additionAfter the addition
2. stirringthe reaction mixture was stirred for an additional 2.5 hours at 0° C. and 30 minutes at room temperature
3. washThe aqueous solution was washed with ethyl acetate (150 mL)
4. extractionextracted with 10% methanol/ethyl acetate twice (500 mL total)
5. additionSodium chloride was added to the aqueous layer
6. extractionthe solution was extracted with 10% isopropanol/ethyl acetate twice (500 mL total)
7. washThe combined organic layers were washed with brine
8. dry with materialdried over magnesium sulfate
9. customthe solvent removed under reduced pressure
10. customThe residue was recrystallized from methanol/isopropanol

ORD record

ord-bc8272e16168420297c966c4f63418e6

Source dataset

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05658930