反应详情

温度

0 °C

1 g of the product of Example E and 0.45 g of potassium fluoride are stirred for 1 hour at room temperature in a mixture of 20 ml of dimethylformamide, 10 ml of chloroform and 1 ml of water. After chloroform has been added, the organic phase is separated off, extracted by shaking with water, dried over sodium sulphate and concentrated. The residue is boiled briefly in 20 ml of methanol. When the mixture has cooled to 0° C., the solid obtained is filtered off with suction and dried. 0.63 g of the title compound is obtained (77% of theory).

1. customthe organic phase is separated off
2. extractionextracted
3. dry with materialdried over sodium sulphate
4. concentrationconcentrated
5. customthe solid obtained
6. filtrationis filtered off with suction
7. customdried