Sodium Iodide → (+/-)-4-((alphaR*)-alpha-((2S*,5R*)-4-(Cyanomethyl)-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

HRID 2258358Notes

Reaction equation

HRID 2258358 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C@H:9]([C:17]1[CH:29]=[CH:28][C:20]([C:21]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[O:22])=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=1.[Si](O[Si](C(C)(C)C)(C)C)(C(C)(C)C)(C)C.Cl[CH2:46][C:47]#[N:48].C(=O)([O-])[O-].[Na+].[Na+].[I-].[Na+]>O1CCCC1>[C:47]([CH2:46][N:6]1[C@H:5]([CH3:8])[CH2:4][N:3]([C@H:9]([C:17]2[CH:18]=[CH:19][C:20]([C:21]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[O:22])=[CH:28][CH:29]=2)[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[C@@H:2]([CH3:1])[CH2:7]1)#[N:48]

Participants

7

Reactant 5

HCID 5238Sodium IodideHCID 7856ChloroacetonitrileHCID 10340Sodium CarbonateHCID 590018TBDMS etherHCID 153522344-[(R)-((2S,5R)-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide

Product 1

HCID 57073064(+/-)-4-((alphaR*)-alpha-((2S*,5R*)-4-(Cyanomethyl)-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(±)-4-((αR*)-α-((2S*,5R*)-2,5-Dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide, tert-butyldimethylsilyl ether (0.51 g, 1.0 mmol, Example 81, infra) was combined with 2-chloroacetonitrile (0.07 mL, 1.1 mmol, Eastman Kodak, Rochester, N.Y.) and sodium carbonate in anhydrous tetrahydrofuran. The reaction mixture was chilled in an ice bath and sodium iodide (0.16 g, 1.1 mmol) was added. The reaction was allowed to warm to room temperature and stirred overnight. The solvent was removed and the residue was redissolved in dichloromethane and washed with water. The solvent was evaporated and the residue was purified by chromatography on silica gel with ethanol (0-3%) in dichloromethane. The product was dissolved in 20 mL of acetonitrile and stirred for 3 hours with tetraethylammonium fluoride hydrate (0.18 g). The solvent was evaporated and the residue was purified by chromatography on silica gel with ethanol (0-3%) in dichloromethane. Crystallization of the product from acetonitrile gave 37 mg of solid, mp 190°-192° C. Calc for C26H34N4O4:C, 71.86; H, 7.88; N, 12.89. Found: C, 71.83; H, 7.94; N, 12.95. NMR (200 MHz, CDCl3): δ0.93 (d, J=6 Hz, 3H); 1.15 (d, J=4.7 Hz, 3H); 1.0-1.2 (br m, 6H); 1.79 (t, J=11 Hz, 1H); 2.2-2.4 (m, 5H); 3.2-3.6 (br m, 4H); 3.36 & 3.76 (ABq, J=17.4 Hz, 2H); 5.15 (s, 1H); 6.55 (s, 1H); 6.57 (d, J=8.6 Hz, 1H); 6.73 (d, J=8 Hz, 1H); 7.13 (t, J=7.6 Hz, 1H); 7.28 & 7.42 (ABq, J=8.2 Hz, 4H).

Workup

  1. temperatureThe reaction mixture was chilled in an ice bath
  2. customThe solvent was removed
  3. dissolutionthe residue was redissolved in dichloromethane
  4. washwashed with water
  5. customThe solvent was evaporated
  6. customthe residue was purified by chromatography on silica gel with ethanol (0-3%) in dichloromethane
  7. dissolutionThe product was dissolved in 20 mL of acetonitrile
  8. stirringstirred for 3 hours with tetraethylammonium fluoride hydrate (0.18 g)
  9. customThe solvent was evaporated
  10. customthe residue was purified by chromatography on silica gel with ethanol (0-3%) in dichloromethane
  11. customCrystallization of the product from acetonitrile

Sources & evidence

ORD record
ord-1824d5e8067346f1bf702bda82f81de4
Source dataset
uspto-grants-1997_08
Patent number
US05658908

Reaction notes

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